(3-Fluoro-4-(4-fluorophenoxy)phenyl)methanol → 8-((3-fluoro-4-(4-fluorophenoxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 920423ノート

反応式

HRID 920423 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:16][OH:17])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1.Cl[C:19]1[CH:29]=[C:23]2[N:24]([CH3:28])[CH2:25][CH2:26][CH2:27][N:22]2[C:21](=[O:30])[N:20]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1)[CH2:16][O:17][C:19]1[CH:29]=[C:23]2[N:24]([CH3:28])[CH2:25][CH2:26][CH2:27][N:22]2[C:21](=[O:30])[N:20]=1

参加物

3

反応物 2

HCID 28946101(3-Fluoro-4-(4-fluorophenoxy)phenyl)methanolHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

生成物 1

HCID 712365628-((3-fluoro-4-(4-fluorophenoxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

実験手順

The title compound or its salt was prepared by a procedure similar to that described for E2 starting from (3-fluoro-4-(4-fluorophenoxyl)phenyl)methanol and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

出典と根拠

ORDレコード
ord-2882940273654d9889e86e28b39ac0ac
出典データセット
uspto-grants-2016_03
特許番号
US09273054B2

反応ノート

読み込み中…