関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Urea | HCID 1176 | — |
| 反応物 | 4-Chloro-5-nitrophthalimide | HCID 2801129 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-Amino-6-nitro-1H-isoindole-1,3(2H)-dione | HCID 15144568 | 92.5% |
反応手順
A mixture of 5-chloro-6-nitroisoindoline-1,3-dione (28.0 g, 0.123 mol) and urea (73.8 g, 1.23 mol) was stirred and heated to 150° C. under argon for 6 h. After cooled to rt, the solid was suspended in hot water (100 mL, 80° C.), filtered, washed with hot water (3×50 mL) and dried under vacuum to give a yellow solid product, 23.56 g, 92.5% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09273055B2 |
|---|
| 出典データセット | uspto-grants-2016_03 |
|---|
| ORD ID | ord-ed47e73b7daf467f93712a427a8e6c1c |
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| 出典メモ | uspto-grants-2016_03 |
|---|
