Morpholine → 3-Morpholinothieno[3,2-c]pyridin-4(5H)-one

HRID 920930ノート

反応式

HRID 920930 の反応式
Br[C:2]1[C:6]2[C:7](=[O:11])[NH:8][CH:9]=[CH:10][C:5]=2[S:4][CH:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>>[O:15]1[CH2:16][CH2:17][N:12]([C:2]2[C:6]3[C:7](=[O:11])[NH:8][CH:9]=[CH:10][C:5]=3[S:4][CH:3]=2)[CH2:13][CH2:14]1

参加物

3

反応物 2

HCID 8083MorpholineHCID 184507963-Bromothieno[3,2-c]pyridin-4(5H)-one

生成物 1

HCID 866831433-Morpholinothieno[3,2-c]pyridin-4(5H)-one収率 42.7%

実験手順

3-Bromothieno[3,2-c]pyridin-4(5H)-one from Example 202.3 (411 mg, 1.786 mmol) and morpholine 81501 mg, 17.23 mmol) were stirred in a microwave for 3 h at 220° C. The mixture was poured onto water and extracted with DCM. The organic phase was concentrated and the residue was recrystallized from EA to give 180 mg (yield: 42.6%) of the title compound.

後処理

  1. additionThe mixture was poured onto water
  2. extractionextracted with DCM
  3. concentrationThe organic phase was concentrated
  4. customthe residue was recrystallized from EA

出典と根拠

ORDレコード
ord-7c7cf88901ce4d718efbd8decd9bb8f8
出典データセット
uspto-grants-2016_03
特許番号
US09273068B2

反応ノート

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