Potassium Carbonate → Methanone,4-morpholinyl[5,6,7,8-tetrahydro-3-(trifluoromethyl)imidazo[1,5-a]pyrazin-1-yl]-

HRID 920981ノート

反応式

HRID 920981 の反応式
Cl.[O:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[N:11]=[C:12]([C:19]([F:22])([F:21])[F:20])[N:13]3[CH2:18][CH2:17][NH:16][CH2:15][C:14]=23)=[O:9])[CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+]>C(OCC)(=O)C>[O:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[N:11]=[C:12]([C:19]([F:21])([F:22])[F:20])[N:13]3[CH2:18][CH2:17][NH:16][CH2:15][C:14]=23)=[O:9])[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 86685646Morpholino-[3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-1-yl]methanone hydrochloride

生成物 1

HCID 68011886Methanone,4-morpholinyl[5,6,7,8-tetrahydro-3-(trifluoromethyl)imidazo[1,5-a]pyrazin-1-yl]-収率 98.6%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Crude morpholino-[3-(trifluoromethyl)-5,6,7,8-tetrahydro imidazo[1,5-a]pyrazin-1-yl]methanone hydrochloride 20c (330 mg, 1 mmol) was dissolved in 10 mL of ethyl acetate, followed by addition of potassium carbonate (10 g, 72 mmol). After stirring for 4 hours, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure to obtain crude morpholino-[3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-1-yl]methanone 20d (300 mg) as a light yellow solid. The product was used directly in the next reaction without purification.

後処理

  1. filtrationthe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-32aa5e5429c9438195581fc1a175171b
出典データセット
uspto-grants-2016_03
特許番号
US09273052B2

反応ノート

読み込み中…