Potassium Carbonate → N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide

HRID 920994ノート

反応式

HRID 920994 の反応式
Cl.[CH:2]1([CH2:5][NH:6][C:7]([C:9]2[N:10]=[C:11]([C:18]([F:21])([F:20])[F:19])[N:12]3[CH2:17][CH2:16][NH:15][CH2:14][C:13]=23)=[O:8])[CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+]>ClCCl>[CH:2]1([CH2:5][NH:6][C:7]([C:9]2[N:10]=[C:11]([C:18]([F:19])([F:20])[F:21])[N:12]3[CH2:17][CH2:16][NH:15][CH2:14][C:13]=23)=[O:8])[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 86685650N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydro imidazo[1,5-a]pyrazine-1-carboxamide hydrochloride

生成物 1

HCID 68011901N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide収率 112.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide hydrochloride 24b (250 mg, 0.77 mmol) was dissolved in 10 mL of dichloromethane, followed by addition of potassium carbonate (320 mg, 2.30 mmol). After stirring for 4 hours, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure to obtain crude N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide 24c (250 mg) as a yellow solid. The product was used directly in the next reaction without purification.

後処理

  1. filtrationthe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-9cfd8df8bd854eabaaa57d9e669a35d5
出典データセット
uspto-grants-2016_03
特許番号
US09273052B2

反応ノート

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