6-Tert-butyl-2-chloropyridine-3-carbonitrile → 6-tert-Butyl-2-(3,3-dimethylbut-1-ynyl)-5-methylnicotinonitrile

反応式

[C:1]([C:5]1[C:12]([CH3:13])=[CH:11][C:8]([C:9]#[N:10])=[C:7](Cl)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].ClC1C(C#N)=C[CH:19]=[C:18]([C:24]([CH3:27])([CH3:26])[CH3:25])N=1>>[C:1]([C:5]1[C:12]([CH3:13])=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:19]#[C:18][C:24]([CH3:27])([CH3:26])[CH3:25])[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

反応物 2

HCID 532788766-Tert-butyl-2-chloropyridine-3-carbonitrile

HCID 866802626-Tert-butyl-2-chloro-5-methylnicotinonitrile

生成物 1

HCID 679954326-tert-Butyl-2-(3,3-dimethylbut-1-ynyl)-5-methylnicotinonitrile

実験手順

Procedure analogous to 31, using 62.6 g (300 mmol) of 6-tert-butyl-2-chloro-5-methylnicotinonitrile, S79, instead of 194.7 g (1 mol) of 2-chloro-3-cyano-6-tert-butylpyridine, S28, and scaling the remaining reagents correspondingly on a molar level. Yield: 68.9 g (271 mmol), 90%. Purity: >95% according to 1H-NMR.

出典と根拠

ORDレコード: ord-06371eb4b0ea4c74a78aa7aba78c49f8
出典データセット: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09273080B2

反応ノート

読み込み中…

参加物