Methanesulfonyl chloride → 6-((tert-Butoxycarbonyl)amino)hexyl methanesulfonate

HRID 921514ノート

反応式

HRID 921514 の反応式
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12].[CH3:16][S:17](Cl)(=[O:19])=[O:18]>C(Cl)Cl>[CH3:16][S:17]([O:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][NH:8][C:9]([O:10][C:11]([CH3:12])([CH3:14])[CH3:13])=[O:15])(=[O:19])=[O:18]

参加物

4

反応物 2

HCID 31297Methanesulfonyl chlorideHCID 4146612tert-Butyl N-(6-hydroxyhexyl)carbamate

生成物 1

HCID 184654786-((tert-Butoxycarbonyl)amino)hexyl methanesulfonate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of tert-butyl (6-hydroxyhexyl)carbamate (12.18 g, 56.05 mmol) and TEA (8.51 g, 84.08 mmol) in 100 ml of methylene chloride, methanesulfonyl chloride (9.63 g, 84.08 mmol) was slowly added at 0° C. The mixture was stirred at room temperature overnight. The compound was purified by silica chromatography using heptane/ethyl acetate as eluent.

後処理

  1. customThe compound was purified by silica chromatography

出典と根拠

ORDレコード
ord-d7d7465185164485b38305dc189586c5
出典データセット
uspto-grants-2016_03
特許番号
US09273343B2

反応ノート

読み込み中…