Lactic Acid → HCID 86662333、化合物

HRID 921990

反応式

HRID 921990 の反応式
[C:1]([OH:6])(=[O:5])[CH:2]([CH3:4])[OH:3].[OH-].[CH2:8]([P+:12]([CH2:21][CH2:22][CH2:23][CH3:24])([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:13][CH2:14][CH2:15][CH3:16])[CH2:9][CH2:10][CH3:11]>CC(C)=O>[C:1]([O-:6])(=[O:5])[CH:2]([CH3:4])[OH:3].[CH2:21]([P+:12]([CH2:8][CH2:9][CH2:10][CH3:11])([CH2:13][CH2:14][CH2:15][CH3:16])[CH2:17][CH2:18][CH2:19][CH3:20])[CH2:22][CH2:23][CH3:24].[C:1]([OH:6])(=[O:5])[CH:2]([CH3:4])[OH:3]

参加物

4

反応物 2

HCID 612Lactic AcidHCID 84487Phosphonium, tetrabutyl-, hydroxide (1:1)

生成物 1

HCID 86662333HCID 86662333、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Lactic acid (5-15 mmol) and tetrabutylphosphonium hydroxide (˜40% sol. in H2O) (3.414 g, 5 mmol) were dissolved in 20 ml of acetone and stirred for 15 min at room temperature. The solvent was evaporated and the remaining viscous liquid was dried at 0.1 mbar with stirring for 24 hrs. 1H-NMR (300 MHz, d6-DMSO) δ(ppm)=3.84 (br s, 1H), 3.44 (q, J=6.7 Hz, 1H), 2.18 (m, 8H), 1.41 (m, 16H), 1.05 (d, J=7.2 Hz, 3H), 0.91 (t, J=6.7 Hz, 12H). 31P-NMR (121.5 MHz, d6-DMSO) δ(ppm)=35.0. 13C-NMR (75 MHz, d6-DMSO) δ(ppm)=176.8, 67.3, 23.72 (d, J=15.5 Hz), 23.01 (d, J=4.7 Hz), 21.91, 17.70 (d, J=47.9 Hz), 13.62 (s).

後処理

  1. customThe solvent was evaporated
  2. customthe remaining viscous liquid was dried at 0.1 mbar
  3. stirringwith stirring for 24 hrs

出典と根拠

ORDレコード
ord-e9c6d42dd0644bca9bd18c739c33c49e
出典データセット
uspto-grants-2016_03
特許番号
US09278134B2

関連ノート

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