1-Methylimidazole → 1-(2-(4-acetamidophenoxy)-2-oxoethyl)-3-methyl-1H-imidazol-3-ium chloride

関与物質

反応手順

4-Acetamidophenyl 2-chloroacetate [2] (1.138 g, 5 mmol) and N-methylimidazol (0.492 g, 6 mmol) were suspended in 50 ml of anhydrous ethyl acetate and refluxed for 48 hrs. After cooling to room temperature the white precipitate was filtered, washed with ethylacetate and diethylether and dried under reduced pressure to give [3] in 79% yield. The product was pure according to 1H NMR and was directly subjected to the next step without further purification.

情報源と証拠