[C:1](=[O:4])([O-])[O-].[NH4+:5].[NH4+:6].[C-]#N.[Na+].[CH3:10][O:11][C:12]1([CH2:19][O:20][CH3:21])[CH2:17][CH2:16][C:15](=O)[CH2:14][CH2:13]1.[CH2:22]([OH:24])C>O>[CH3:10][O:11][C:12]1([CH2:19][O:20][CH3:21])[CH2:17][CH2:16][C:15]2([NH:6][C:22](=[O:24])[NH:5][C:1]2=[O:4])[CH2:14][CH2:13]15.74 g (59.7 mmol) of ammonium carbonate and 1.46 g (29.8 mmol) of sodium cyanide were dissolved in 33 ml of water. 2.57 g (14.9 mmol) of a solution of the compound from Example 12A in 33 ml of ethanol were added dropwise at room temperature and the mixture was stirred at 60° C. overnight. The reaction mixture was concentrated to a quarter of its original volume and extracted repeatedly with dichloromethane and ethyl acetate, and the organic phases were dried over sodium sulphate, filtered and concentrated. This gave 675 mg (19% of theory) of the title compound as a diastereomer mixture which was reacted without further purification.
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