Methanamine, N-methoxy-, hydrochloride (1:1) → 1-(5-Bromo-6-methoxypyridin-3-yl)ethan-1-one
反応式
[Br:1][C:2]1[C:3]([O:11][CH3:12])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.Cl.[CH3:14]NOC.C[Mg]Br>>[Br:1][C:2]1[CH:10]=[C:6]([C:7](=[O:9])[CH3:14])[CH:5]=[N:4][C:3]=1[O:11][CH3:12]参加物
4
実験手順
5-Bromo-6-methoxynicotinic acid and N,O-dimethylhydroxylamine hydrochloride were treated in the similar manner to Reference Example 7(5), and then the resulting compound and methylmagnesium bromide were treated in the similar manner to Reference Example 7(6) to give 1-(5-bromo-6-methoxypyridin-3-yl)ethanone [Ex(296-1)] as a colorless powder.
出典と根拠
- ORDレコード
- ord-df787c6a77c74c04923310bf2b837528
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09278944B2
反応ノート
読み込み中…