Hydrochloric Acid → Ethyl 4-hydroxybenzofuran-6-carboxylate

HRID 922439ノート

反応式

HRID 922439 の反応式
C([O:4][C:5]1[C:10]2[CH:11]=[CH:12][O:13][C:9]=2[CH:8]=[C:7]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:6]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+].Cl>C(O)C>[OH:4][C:5]1[C:10]2[CH:11]=[CH:12][O:13][C:9]=2[CH:8]=[C:7]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:6]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 675451626-Benzofurancarboxylic acid, 4-(acetyloxy)-, ethyl ester

生成物 1

HCID 11344757Ethyl 4-hydroxybenzofuran-6-carboxylate収率 95.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of the compound obtained in the above (1) (24.7 g) in ethanol (150 mL) was added potassium carbonate (42.0 g), and the mixture was heated to reflux for 30 minutes. The reaction mixture was ice-cooled, and then acidified by 10% hydrochloric acid, and then extracted with ethyl acetate. The organic layer was washed with saturated saline, dried over sodium sulfate, and then concentrated under reduced pressure. The resulting residue was triturated with n-hexane-dichloromethane (5:1) to give ethyl 4-hydroxy-1-benzofuran-6-carboxylate [REx(7-1)] (19.6 g) as a pale yellow powder.

後処理

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 30 minutes
  3. temperaturecooled
  4. extractionextracted with ethyl acetate
  5. washThe organic layer was washed with saturated saline
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated under reduced pressure
  8. customThe resulting residue was triturated with n-hexane-dichloromethane (5:1)

出典と根拠

ORDレコード
ord-3593af004da64766a74ae4905e6e0957
出典データセット
uspto-grants-2016_03
特許番号
US09278944B2

反応ノート

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