Acetyl chloride → 1-(6-Methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-one

HRID 922440ノート

反応式

HRID 922440 の反応式
[CH3:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[CH:10][C:5]2=[CH:4][CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[C:15](Cl)(=[O:17])[CH3:16].C(=O)([O-])O.[Na+]>ClC(Cl)C>[CH3:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[C:10]([C:15](=[O:17])[CH3:16])[C:5]2=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 6367Acetyl chlorideHCID 516892Sodium BicarbonateHCID 6451240Aluminum(III) ChlorideHCID 114577166-Methyl-1H-pyrrolo[2,3-b]pyridine

生成物 1

HCID 683086561-(6-Methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-one

試薬・触媒・溶媒 1

HCID 63651,1-Dichloroethane溶媒

実験手順

To a solution of 6-methyl-1H-pyrrolo[2,3-b]pyridine (500 mg) in dichloroethane (6 mL) were added aluminum chloride (1.09 g) and acetyl chloride (0.40 mL), and then the mixture was stirred at room temperature for 1.5 hours. The reaction solution was poured into aqueous saturated sodium hydrogen carbonate solution, and extracted with chloroform. The organic layer was washed with saturated saline, dried over magnesium sulfate, and then concentrated under reduced pressure. The resulting residue was triturated with isopropyl ether to 1-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone [REx(8-1)] (481 mg) as a yellow powder.

後処理

  1. extractionextracted with chloroform
  2. washThe organic layer was washed with saturated saline
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customThe resulting residue was triturated with isopropyl ether to 1-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone [REx(8-1)] (481 mg) as a yellow powder

出典と根拠

ORDレコード
ord-b6a6fd5c48e14501bfbf662271d3427f
出典データセット
uspto-grants-2016_03
特許番号
US09278944B2

反応ノート

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