hydrogen chloride CPME → N-[4-(trans-2-aminocyclopropyl)-2-methylphenyl]benzamide hydrochloride
反応式
[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C@@H:16]2[CH2:18][C@H:17]2[NH:19]C(=O)OC(C)(C)C)=[CH:12][C:11]=1[CH3:27])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:28].COC1CCCC1>>[ClH:28].[NH2:19][C@@H:17]1[CH2:18][C@H:16]1[C:13]1[CH:14]=[CH:15][C:10]([NH:9][C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[C:11]([CH3:27])[CH:12]=1参加物
3
実験手順
tert-Butyl {trans-2-[4-(benzoylamino)-3-methylphenyl]cyclopropyl}carbamate (125.8 mg) was dissolved in 4N hydrochloric acid/cyclopentyl methyl ether solution (1.5 mL), and the mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure to give the title compound (95.9 mg).
後処理
- customThe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-b95ec5a89708440e9cc9ff1fdf103d08
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09278931B2
反応ノート
読み込み中…