4-Bromophenol → 1-Bromo-4-(cyclobutyloxy)benzene
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH:9]1(Br)[CH2:12][CH2:11][CH2:10]1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH:9]2[CH2:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1参加物
5
反応条件
- 温度
- 120 °C
実験手順
The mixture of 2.50 g (14.5 mmol) of 4-bromophenol, 2.04 ml (21.7 mmol) of cyclobutyl bromide and 7.99 g (57.8 mmol) of K2CO3 in 25 ml DMF is stirred at 120° C. over night. The reaction mixture is extracted with water and EtOAc. The organic layer is dried, filtered and the solvent is removed in vacuo.
後処理
- extractionThe reaction mixture is extracted with water and EtOAc
- customThe organic layer is dried
- filtrationfiltered
- customthe solvent is removed in vacuo
出典と根拠
- ORDレコード
- ord-b2861fa63ec54c5ea13073049c443bb2
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09278954B2
反応ノート
読み込み中…