Potassium Hydroxide → HCID 86719692、化合物

HRID 922664ノート

反応式

HRID 922664 の反応式
[Cl:1][C:2]1[N:3]=[CH:4][NH:5][C:6]=1[Cl:7].[OH-:8].[K+].[Br:10][CH2:11][C:12]1[CH:25]=[CH:24][C:23]2[C:22](=[O:26])[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15](=[O:27])[C:14]=2[CH:13]=1>CN(C=O)C>[Br-:10].[CH3:11][C:12]1[CH:25]=[CH:24][C:23]2[C:22](=[O:26])[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15](=[O:27])[C:14]=2[C:13]=1[N+:3]1[C:2]([Cl:1])=[C:6]([Cl:7])[N:5]([C:13]2[C:14]3[C:15](=[O:8])[C:16]4[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=4)[C:22](=[O:26])[C:23]=3[CH:24]=[CH:25][C:12]=2[CH3:11])[CH:4]=1

参加物

5

反応物 3

HCID 14797Potassium HydroxideHCID 1400184,5-DichloroimidazoleHCID 3444522-Bromomethyl-anthraquinone

生成物 1

HCID 86719692HCID 86719692、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

反応条件

温度
80 °C

実験手順

4,5-Dichloroimidazole (0.14 g, 1.0 mmol) and potassium hydroxide (0.06 g, 1.1 mmol) will be dissolved in the minimum volume of DMF in a high-pressure vessel. The solution will be heated at 80° C. for 30 min. The vessel will be removed from heat and 2-(bromomethyl)anthraquinone (1.20 g, 4.0 mmol) will be added. If not all solid dissolves, DMF will be added until all reactants are in solution. The vessel will be sealed and heated at 100° C. for 12 h. The volatile components will be removed under reduced pressure, and the remaining mixture washed with water to remove potassium bromide. The remaining solid will be collected and should be the product.

後処理

  1. customThe vessel will be removed
  2. temperaturefrom heat
  3. dissolutionIf not all solid dissolves
  4. customThe vessel will be sealed
  5. temperatureheated at 100° C. for 12 h
  6. customThe volatile components will be removed under reduced pressure
  7. washthe remaining mixture washed with water
  8. customto remove potassium bromide
  9. customThe remaining solid will be collected

出典と根拠

ORDレコード
ord-6be74805d4c24c80a7e3c53051eaf821
出典データセット
uspto-grants-2016_03
特許番号
US09278951B2

反応ノート

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