Hydrazine → (2S)-2-(4-Fluorophenyl)propan-1-amine
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([CH3:21])[CH2:9][N:10]2C(=O)C3C(=CC=CC=3)C2=O)=[CH:4][CH:3]=1.NN>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]([CH3:21])[CH2:9][NH2:10])=[CH:6][CH:7]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
To a room-temperature solution of (S)-2-(2-(4-fluorophenyl)propyl)isoindoline-1,3-dione (900 mg, 3.2 mmol, 1.0 equiv) in toluene (14 mL) was added hydrazine (1.4 mL, 45 mmol, 14 equiv) by syringe. The resulting mixture was heated to 80° C. for 30 minutes and then cooled to room temperature. The resulting solution was decanted from the solid in the reaction mixture, and the solid was washed with additional toluene. The combined organic layers were concentrated in vacuo to provide the title compound (491 mg, 99%), which was used without further purification. m/z=154.2 [M+H]+.
後処理
- temperaturecooled to room temperature
- customThe resulting solution was decanted from the solid in the reaction mixture
- washthe solid was washed with additional toluene
- concentrationThe combined organic layers were concentrated in vacuo
出典と根拠
- ORDレコード
- ord-c830a77e07d041a5b1b419899799c294
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09278962B2
反応ノート
読み込み中…