N-(Phenylmethyl)thiourea → N-benzyl-4-(pyridin-2-yl)thiazol-2-amine

HRID 922871

反応式

HRID 922871 の反応式
Br.Br[CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1)=O.[CH2:12]([NH:19][C:20]([NH2:22])=[S:21])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(O)C>[CH2:12]([NH:19][C:20]1[S:21][CH:3]=[C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=2)[N:22]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 737375N-(Phenylmethyl)thioureaHCID 27762312-Bromo-1-(2-pyridinyl)-1-ethanone hydrobromide

生成物 1

HCID 2902584N-benzyl-4-(pyridin-2-yl)thiazol-2-amine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 2-(Bromoacetyl)pyridine hydrobromide (100 mg, 0.36 mmol) in ethanol (2 mL) was treated with 1-benzyl-2-thiourea (90 mg, 0.54 mmol). The resulting yellow solution was concentrated, and the crude residue was purified on reverse phase HPLC to produce N-benzyl-4-(pyridin-2-yl)thiazol-2-amine.

後処理

  1. concentrationThe resulting yellow solution was concentrated
  2. customthe crude residue was purified on reverse phase HPLC

出典と根拠

ORDレコード
ord-fa71e5a2bfe44609b4e6e8bc627e0b2d
出典データセット
uspto-grants-2016_03
特許番号
US09278961B2

関連ノート

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