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Chlorosuccinimide → N-benzyl-5-chloro-4-(pyridin-2-yl)thiazol-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chlorosuccinimide | HCID 31398 | — |
| 反応物 | N-benzyl-4-(pyridin-2-yl)thiazol-2-amine | HCID 2902584 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-benzyl-5-chloro-4-(pyridin-2-yl)thiazol-2-amine | HCID 58614641 | — |
反応手順
A solution of N-benzyl-4-(pyridin-2-yl)thiazol-2-amine (60 mg, 0.23 mmol) in DMF (2 mL) was cooled to 0° C. and treated with N-chlorosuccinimide (33 mg, 0.25 mmol), and the reaction mixture was allowed to warm to room temperature. The solvent was evaporated, and the product was purified on reverse phase HPLC to produce N-benzyl-5-chloro-4-(pyridin-2-yl)thiazol-2-amine. MS (Q1) 302.2 (M)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09278961B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-633c0b3efab743debbe6075fbd2ec801 |
| 出典メモ | uspto-grants-2016_03 |