反応式
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1.[F:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[C:26]([CH3:27])=[C:25]([C:28](O)=[O:29])[CH:24]=[N:23]2)=[CH:18][CH:17]=1>>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:28]([C:25]2[CH:24]=[N:23][N:22]([C:19]3[CH:20]=[CH:21][C:16]([F:15])=[CH:17][CH:18]=3)[C:26]=2[CH3:27])=[O:29])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1参加物
3
実験手順
50 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxamide. MS (Q1) 407.0 (M)+.
後処理
- customThe product was purified on reverse phase HPLC
出典と根拠
- ORDレコード
- ord-e9842021494641f0aebfe1fca0259d30
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09278961B2
関連ノート
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