Acetic Anhydride → 1-Acetyl-1H-indazole-5-carboxylic acid

HRID 923309ノート

反応式

HRID 923309 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]([OH:12])=[O:11])=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[C:13](OC(=O)C)(=[O:15])[CH3:14]>CC(O)=O.CCCCCC>[C:13]([N:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]([OH:12])=[O:11])=[CH:7][CH:8]=2)[CH:3]=[N:2]1)(=[O:15])[CH3:14]

参加物

5

反応物 2

HCID 7918Acetic AnhydrideHCID 42484541H-Indazole-5-carboxylic acid

生成物 1

HCID 675623731-Acetyl-1H-indazole-5-carboxylic acid収率 78.5%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 8058Hexane溶媒

反応条件

温度
80 °C

実験手順

To a solution of 1H-indazole-5-carboxylic acid (8.6 g, 53.04 mmol) in AcOH (200 ml) was added acetic anhydride (16.2 g), and the reaction was stirred for 2.5 h at 80° C. The resulting solution was diluted with n-hexane (400 ml). The solids were collected by filtration and washed with hexane (5×100 ml) to afford 1-acetyl-1H-indazole-5-carboxylic acid as an orange solid (8.5 g, 78%).

後処理

  1. filtrationThe solids were collected by filtration
  2. washwashed with hexane (5×100 ml)

出典と根拠

ORDレコード
ord-3a3bb6951d4d49e3a588653a86cb29b4
出典データセット
uspto-grants-2016_03
特許番号
US09278973B2

反応ノート

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