化工社化工社 化学情報印刷レポート · 研究参考用
2-(Methylamino)ethanol → 5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-((2-hydroxyethyl)(methyl)amino)nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Methylamino)ethanol | HCID 8016 | — |
| 反応物 | 5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamide | HCID 72546089 | — |
| 生成物 | 5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-((2-hydroxyethyl)(methyl)amino)nicotinamide | HCID 89906702 | — |
反応手順
The title compound was prepared in an analogous fashion to that described in Stage 33.1 using 5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamide (Stage 169.2) and 2-methylamino-ethanol to afford as a white crystalline solid. HPLC (Condition 4) tR=5.72 min, UPLC-MS (Condition 3) tR=1.14 min, m/z=452.2 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09278981B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-5443036183fc489c9d23936be8d34255 |
| 出典メモ | uspto-grants-2016_03 |