Benzene, 1-(1,1-difluoroethoxy)-4-nitro- → Benzenamine, 4-(1,1-difluoroethoxy)-
反応式
[F:1][C:2]([F:14])([O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][CH:6]=1)[CH3:3]>CCO.[Ni]>[F:1][C:2]([F:14])([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)[CH3:3]参加物
4
実験手順
A solution of 1-(1,1-difluoroethoxy)-4-nitrobenzene (Stage 30.4, 2.95 g, 13.94 mmol) in EtOH (100 mL) was hydrogenated (Raney Ni 1.0 g; 26.5 h at RT). The RM was filtered through Hyflo® and the solvent was evaporated off under reduced pressure to give the crude title product as a brown oil. HPLC (Condition 5) tR=4.5 min, UPLC-MS (Condition 3) tR=0.74 min, m/z=174.1 [M+H]+.
後処理
- filtrationThe RM was filtered through Hyflo®
- customthe solvent was evaporated off under reduced pressure
出典と根拠
- ORDレコード
- ord-068c464ffd144dc8839a2dedbb10a8be
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09278981B2
反応ノート
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