Hydrochloric Acid → (3S,4S)-4-Aminopyrrolidin-3-ol dihydrochloride

HRID 924123ノート

反応式

HRID 924123 の反応式
[NH2:1][C@@H:2]1[C@@H:6]([OH:7])[CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.CCO.[ClH:18]>>[ClH:18].[ClH:18].[NH2:1][C@H:2]1[CH2:3][NH:4][CH2:5][C@@H:6]1[OH:7]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 104654571-Boc-(3S,4S)-3-amino-4-hydroxypyrrolidine

生成物 1

HCID 69959682(3S,4S)-4-Aminopyrrolidin-3-ol dihydrochloride

実験手順

(3S,4S)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate (0.3 g, 1.439 mmol) in 1.25 M HCl 1.25 M in EtOH (11.51 mL, 14.39 mmol) was stirred for 24 h at RT. The white suspension was evaporated to dryness under reduced pressure and the residue was suspended in MeOH (10 mL) and evaporated again to afford the title compound.

後処理

  1. customThe white suspension was evaporated to dryness under reduced pressure
  2. customevaporated again

出典と根拠

ORDレコード
ord-f55e85da7c6f42ddb636bea58c38c01a
出典データセット
uspto-grants-2016_03
特許番号
US09278981B2

反応ノート

読み込み中…