Potassium Hydroxide → 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid

HRID 924624

反応式

HRID 924624 の反応式
[CH2:1]([O:3][C:4](=[O:13])[C:5]([CH3:12])([CH3:11])[C:6]([O:8]CC)=[O:7])[CH3:2].[OH-].[K+]>C(O)C>[CH2:1]([O:3][C:4](=[O:13])[C:5]([CH3:12])([CH3:11])[C:6]([OH:8])=[O:7])[CH3:2]

参加物

4

反応物 2

HCID 14797Potassium Hydroxide2 回HCID 15382Diethyl dimethylmalonate

生成物 1

HCID 2317543-Ethoxy-2,2-dimethyl-3-oxopropanoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

25 g 2,2-Dimethyl-malonic acid diethyl ester, 7.8 g potassium hydroxide and 500 ml ethanol were mixed in a round-bottomed flask and refluxed for 3 hours. Then again 2.2 g potassium hydroxide were added and the mixture was refluxed overnight. The solvent was removed on a rotovap, 250 ml H2O were added and the mixture was washed with ether. The aqueous phase was acidified with HCl to pH 3-4 followed by two extractions with dichloromethane. The organic solvent was dried and evaporated and the resulting product was characterized by 1H-NMR.

後処理

  1. temperaturerefluxed for 3 hours
  2. temperaturethe mixture was refluxed overnight
  3. customThe solvent was removed on a rotovap, 250 ml H2O
  4. additionwere added
  5. washthe mixture was washed with ether
  6. extractionfollowed by two extractions with dichloromethane
  7. customThe organic solvent was dried
  8. customevaporated

出典と根拠

ORDレコード
ord-d05ddce2c4654619837edad593ea50d2
出典データセット
uspto-grants-2016_03
特許番号
US09283186B2

関連ノート

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