4-Bromo-1,2-dichlorobenzene → 1-(3,4-Dichlorophenyl)-2-phenylethanone

反応式

Cl[C:2]1[CH:3]=[C:4]([C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.BrC1C=CC([Cl:25])=C(Cl)C=1>>[Cl:8][C:6]1[CH:5]=[C:4]([C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:3]=[CH:2][C:7]=1[Cl:25]

参加物

反応物 2

HCID 290134-Bromo-1,2-dichlorobenzene

HCID 27581461-(3,5-Dichlorophenyl)-2-phenylethanone

生成物 1

HCID 27581451-(3,4-Dichlorophenyl)-2-phenylethanone収率 42.4%

実験手順

Prepared following the procedure described in Intermediate 13, starting from 4-bromo-1,2-dichlorobenzene, where the crude product was purified by column chromatography (PE:EtOAc=100:1) to afford Intermediate 19 (230 mg, yield 42.4%).

後処理

customPrepared
customwas purified by column chromatography (PE:EtOAc=100:1)

出典と根拠

ORDレコード: ord-dbbfbf9773f94286b81bb5dbc7847974
出典データセット: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09283229B2

反応ノート

読み込み中…

参加物