Benzylamine → HCID 178483386、化合物
反応式
Br.[CH3:2][N:3]([CH3:25])[CH2:4][CH2:5][CH2:6][C:7]1([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[C:11]2[CH:12]=[CH:13][C:14]([C:16]#[N:17])=[CH:15][C:10]=2[CH2:9][O:8]1.[CH2:26]([NH2:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH2:26]([NH:33][C:16]([C:14]1[CH:13]=[CH:12][C:11]2[C:7]([CH2:6][CH2:5][CH2:4][N:3]([CH3:25])[CH3:2])([C:18]3[CH:19]=[CH:20][C:21]([F:24])=[CH:22][CH:23]=3)[O:8][CH2:9][C:10]=2[CH:15]=1)=[NH:17])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1参加物
3
反応条件
- 温度
- 80 °C
実験手順
Using 250 mg of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile hydrobromide (citalopram HBr) and benzylamine (1.2 equiv) gave, after heating at 80° C. for 14 h, title product (72 mg, 19% yield) as a white solid.
後処理
- customgave
出典と根拠
- ORDレコード
- ord-dd149e718ed94f10b2fe0117b741fac5