Ammonium Hydroxide → 2,2,2-Trifluoroethane-1-sulfonamide

HRID 9253ノート

反応式

HRID 9253 の反応式
[C:1]([CH2:5][S:6](Cl)(=[O:8])=[O:7])([F:4])([F:3])[F:2].[NH4+:10].[OH-]>C(Cl)Cl.O>[C:1]([CH2:5][S:6]([NH2:10])(=[O:8])=[O:7])([F:4])([F:3])[F:2]

参加物

5

反応物 2

HCID 14923Ammonium HydroxideHCID 742422,2,2-Trifluoroethanesulfonyl chloride

生成物 1

HCID 212655462,2,2-Trifluoroethane-1-sulfonamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

The CF3CH2SO2NH2 was prepared by cooling a solution of commercially available CF3CH2SO2Cl (0.6 ml, 1 eq) in CH2Cl2 to 0° C. NH4OH (0.75 ml, 14.8 N, 2 eq) was then added dropwise. The mixture was allowed to warm to room temperature overnight. The reaction was diluted with water and extracted three times with CH2Cl2. The combined organic layers were dried with Na2SO4 and concentrated. The sulfonamide was used without further purification.

後処理

  1. extractionextracted three times with CH2Cl2
  2. dry with materialThe combined organic layers were dried with Na2SO4
  3. concentrationconcentrated
  4. customThe sulfonamide was used without further purification

出典と根拠

ORDレコード
ord-e82600096dac46b5b34ea78698e65332
出典データセット
uspto-grants-2006_08
特許番号
US07091230B2

反応ノート

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