Iodine → HCID 18541883、化合物

HRID 925330ノート

反応式

HRID 925330 の反応式
[I:1]I.[F:3][C:4]1[CH:5]=[C:6]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[NH2:7]>C(O)C.S([O-])([O-])(=O)=O.[Ag+2]>[F:3][C:4]1[C:5]([I:1])=[C:6]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[NH2:7]

参加物

5

反応物 2

HCID 807IodineHCID 27249913,4,5-Trifluoroaniline

生成物 1

HCID 18541883HCID 18541883、化合物収率 42%

試薬・触媒・溶媒 2

HCID 178418844HCID 178418844、化合物触媒HCID 702Ethanol溶媒

実験手順

3,4,5-trifluoro-2-iodoaniline was prepared according to method D Step I with iodine (0.621 g; 2.45 mmol), silver sulphate (0.763 g; 2.45 mmol) and 3,4,5-trifluoroaniline (0.360 g; 2.45 mmol) in ethanol (5 mL). The crude residue was purified by flash chromatography on silica gel (eluent 2 to 40% ethyl acetate in heptane) to yield 0.279 g (42%) of 3,4,5-trifluoro-2-iodoaniline as a white solid.

後処理

  1. custom3,4,5-trifluoro-2-iodoaniline was prepared
  2. customThe crude residue was purified by flash chromatography on silica gel (eluent 2 to 40% ethyl acetate in heptane)

出典と根拠

ORDレコード
ord-20ffaf9827c4465faa6c13e7162884cb
出典データセット
uspto-grants-2016_03
特許番号
US09284271B2

反応ノート

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