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Triethylamine → N-(2-(5-chloro-1H-indol-3-yl)ethyl)-6-morpholinonicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 6-Morpholinonicotinoyl Chloride | HCID 2776461 | — |
| 反応物 | 5-Chloro-1H-indole-3-ethylamine monohydrochloride | HCID 2827494 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(2-(5-chloro-1H-indol-3-yl)ethyl)-6-morpholinonicotinamide | HCID 67972953 | 57% |
反応手順
N-(2-(5-chloro-1H-indol-3-yl)ethyl)-6-morpholinonicotinamide was obtained following Method C starting from 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.042 g, 0.178 mmol), 6-morpholinonicotinoyl chloride (0.045 g; 0.178 mmol), and triethylamine (0.062 mL; 0.446 mmol) in dichloromethane (5 mL). Flash chromatography on silica gel (eluent 1 to 10% methanol in dichloromethane) furnished 0.039 g (57%) of N-(2-(5-chloro-1H-indol-3-yl)ethyl)-6-morpholinonicotinamide as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09284271B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-da783714262d4fa3aa320c7d4195c129 |
| 出典メモ | uspto-grants-2016_03 |