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Triethylamine → N-(2-(5-Methyl-1H-indol-3-yl)ethyl)biphenyl-4-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | 4-Phenylbenzoyl chloride | HCID 84151 | — |
| 反応物 | 5-Methyltryptamine hydrochloride | HCID 6917145 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(2-(5-Methyl-1H-indol-3-yl)ethyl)biphenyl-4-carboxamide | HCID 1870500 | 73% |
反応手順
N-(2-(5-Methyl-1H-indol-3-yl)ethyl)biphenyl-4-carboxamide was obtained following Method C starting from 2-(5-methyl-1H-indol-3-yl)ethanamine hydrochloride (0.080 g, 0.372 mmol), biphenyl-4-carbonyl chloride (0.0864 g; 0.391 mmol), and triethylamine (0.131 mL; 0.930 mmol) in dichloromethane (5 mL). Flash chromatography on silica gel eluting with 1 to 10% ethyl acetate in dichloromethane furnished 0.096 g (73%) of N-(2-(5-Methyl-1H-indol-3-yl)ethyl)biphenyl-4-carboxamide as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09284271B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-849fda2dc8914b0ba2feaf5548fb84f6 |
| 出典メモ | uspto-grants-2016_03 |