Ammonia → HCID 89739572、化合物
反応式
[NH3:1].Br[CH2:3][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[N+:13]([O-:15])=[O:14])[C:7]([OH:9])=[O:8]>C(O)C>[NH2:1][CH2:3][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[N+:13]([O-:15])=[O:14])[C:7]([OH:9])=[O:8]参加物
4
反応条件
- 温度
- -78 °C
実験手順
An aqueous solution of 25% w/v ammonia (100 mL) was treated with EtOH (200 mL) and cooled to −78° C. The mixture was slowly treated with a cooled (−78° C.) solution of the benzylbromide (2.58 g, 10.0 mmol) in ethanol (100 mL). The mixture was then allowed to come to room temperature and stirred for 48 h. The mixtures were evaporated under reduced pressure and the residue solid was washed with CH2Cl2 to afford 3-(aminomethyl)-4-nitrobenzoic acid (1.7 g, 87% yield).
後処理
- additionThe mixture was slowly treated with
- customto come to room temperature
- customThe mixtures were evaporated under reduced pressure
- washthe residue solid was washed with CH2Cl2
出典と根拠
- ORDレコード
- ord-2c799aa0333a4e54a15f7bc6b8881051
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09284299B2
反応ノート
読み込み中…