Ammonia methanol → 5-Bromo-3-methylpyridine-2-carboxamide
反応式
C([O:3][C:4]([C:6]1[C:11]([CH3:12])=[CH:10][C:9]([Br:13])=[CH:8][N:7]=1)=O)C.[NH3:14].CO>>[Br:13][C:9]1[CH:10]=[C:11]([CH3:12])[C:6]([C:4]([NH2:14])=[O:3])=[N:7][CH:8]=1参加物
3
実験手順
5-Bromo-3-methyl-pyridine-2-carboxylic acid ethyl ester (2.44 g, 10 mmol) was dissolved in NH3/MeOH (50 ml) and heated to reflux for 3 days. The reaction mixture was concentrated to give the desired product as a pink solid (2.05 g, 9.6 mmol).
後処理
- temperatureheated
- temperatureto reflux for 3 days
- concentrationThe reaction mixture was concentrated
出典と根拠
- ORDレコード
- ord-ec17b29b8ff54250b0977df129b33a17
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09284284B2
反応ノート
読み込み中…