Ethyl orthoformate → HCID 178518012、化合物
反応式
[NH2:1][C:2]1[C:3]([C:12]([NH2:14])=[O:13])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH2:15](OC(OCC)OCC)C>>[F:10][C:8]([F:11])([F:9])[C:6]1[CH:5]=[N:4][C:3]2[C:12]([OH:13])=[N:14][CH:15]=[N:1][C:2]=2[CH:7]=1参加物
3
反応条件
- 温度
- 120 °C
実験手順
A mixture of 3-amino-5-trifluoromethyl-pyridine-2-carboxylic acid amide (500 mg, 2.44 mmol) and triethoxymethane (1.8 g, 12.2 mmol) were heated to 120° C. for 16 h. The mixture was cooled to ambient temperature and treated with low boiling PE. The reaction mixture was stirred for 10 minutes, cooled to 0° C. and the beige solid was collected by filtration (350 mg).
後処理
- temperatureThe mixture was cooled to ambient temperature
- additiontreated with low boiling PE
- temperaturecooled to 0° C.
- filtrationthe beige solid was collected by filtration (350 mg)
出典と根拠
- ORDレコード
- ord-95c61101f97141a385c08a694088815e
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09284284B2
反応ノート
読み込み中…