Hydrochloric Acid → 8-(4-Hydroxy-phenyl)-1-propyl-1,7-dihydro-purin-6-one

HRID 925539ノート

反応式

HRID 925539 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:16](COCC[Si](C)(C)C)[C:15]3[C:14](=[O:25])[N:13]([CH2:26][CH2:27][CH3:28])[CH:12]=[N:11][C:10]=3[N:9]=2)=[CH:4][CH:3]=1.Cl>C(O)C>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:16][C:15]3[C:14](=[O:25])[N:13]([CH2:26][CH2:27][CH3:28])[CH:12]=[N:11][C:10]=3[N:9]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 1363910238-(4-Hydroxy-phenyl)-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one

生成物 1

HCID 1363910248-(4-Hydroxy-phenyl)-1-propyl-1,7-dihydro-purin-6-one収率 95%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
85 °C

実験手順

A mixture of 8-(4-hydroxy-phenyl)-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one (0.03 g, 0.075 mmol), 2N HCl (1 ml), ethanol (2 ml) was heated at 85° C. for 2 hours. The mixture was cooled and the solvent was evaporated. The residue was washed with n-pentane to obtain 8-(4-Hydroxy-phenyl)-1-propyl-1,7-dihydro-purin-6-one (0.019 g, 95%) as a yellow solid.

後処理

  1. temperatureThe mixture was cooled
  2. customthe solvent was evaporated
  3. washThe residue was washed with n-pentane

出典と根拠

ORDレコード
ord-4e599a5a7cfe47cc8b0789a6ea8b335c
出典データセット
uspto-grants-2016_03
特許番号
US09284316B2

反応ノート

読み込み中…