Phenylboronic Acid → 8-Fluoro-6-phenyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
反応式
Br[C:2]1[C:10]2[N:9]3[CH2:11][CH2:12][NH:13][C:14](=[O:15])[C:8]3=[CH:7][C:6]=2[CH:5]=[C:4]([F:16])[CH:3]=1.[C:17]1(B(O)O)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[F:16][C:4]1[CH:3]=[C:2]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:10]2[N:9]3[CH2:11][CH2:12][NH:13][C:14](=[O:15])[C:8]3=[CH:7][C:6]=2[CH:5]=1参加物
3
実験手順
The title compound, grey solid (52 mg, 74%), MS (ISP) m/z=281.3 [(M+H)+], mp 236.5° C., was prepared in accordance with the general method of example 1 from 6-bromo-8-fluoro-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (intermediate 1) (70.8 mg, 0.25 mmol) and commercially available phenylboronic acid (39.6 mg, 0.325 mmol).
出典と根拠
- ORDレコード
- ord-c3f7339ff66c40bfb71ecd2b1ed22c8b
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09284321B2
反応ノート
読み込み中…