4-Cyanophenylboronic acid → HCID 118341172、化合物
反応式
Br[C:2]1[C:10]2[N:9]3[CH2:11][CH2:12][CH2:13][NH:14][C:15](=[O:16])[C:8]3=[C:7]([CH3:17])[C:6]=2[CH:5]=[C:4]([C:18]#[N:19])[CH:3]=1.[C:20]([C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][CH:23]=1)#[N:21]>>[C:20]([C:22]1[CH:27]=[CH:26][C:25]([C:2]2[C:10]3[N:9]4[CH2:11][CH2:12][CH2:13][NH:14][C:15](=[O:16])[C:8]4=[C:7]([CH3:17])[C:6]=3[CH:5]=[C:4]([C:18]#[N:19])[CH:3]=2)=[CH:24][CH:23]=1)#[N:21]参加物
3
実験手順
The title compound, white solid (30 mg, 35%), MS (ISP) m/z=341.6 [(M+H)+], mp 314° C., was prepared in accordance with the general method of example 1 from 7-bromo-11-methyl-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-9-carbonitrile (intermediate 17) (79.5 mg, 0.25 mmol) and commercially available 4-cyanophenylboronic acid (47.8 mg, 0.325 mmol).
出典と根拠
- ORDレコード
- ord-e1daa8172bdd48bc8e5368a831a0af3d
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09284321B2
反応ノート
読み込み中…