4-(Propan-2-yl)-1,3-thiazole-2-carbonyl chloride → 4-Cyclobutylthiazole-2-carbonyl chloride

反応式

[CH:1]1([C:5]2[N:6]=[C:7]([C:10]([O-:12])=O)[S:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[Li+].C(C1N=C(C([Cl:24])=O)SC=1)(C)C>>[CH:1]1([C:5]2[N:6]=[C:7]([C:10]([Cl:24])=[O:12])[S:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

参加物

反応物 2

HCID 575787964-(Propan-2-yl)-1,3-thiazole-2-carbonyl chloride

HCID 86646409Lithium 4-cyclobutylthiazole-2-carboxylate

生成物 1

HCID 866464084-Cyclobutylthiazole-2-carbonyl chloride

実験手順

4-Cyclobutylthiazole-2-carbonyl chloride 267b was synthesized from compound 266b (5 g, 1 eq.), following the procedure as described for compound 214. MS (ESI, EI+): m/z=198 (MH+).

出典と根拠

ORDレコード: ord-7e58b07eec26417780996eccfb061ccd
出典データセット: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09284307B2

反応ノート

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