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Ethyl 4,6-dimethoxypyrimidine-2-carboxylate → 4,6-Dimethoxypyrimidin-2-carboxylic acid amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 4,6-dimethoxypyrimidine-2-carboxylate | HCID 4449183 | — |
| 反応物 | Ammonia methanol | HCID 21705897 | — |
| 生成物 | 4,6-Dimethoxypyrimidin-2-carboxylic acid amide | HCID 58282682 | 100% |
反応手順
Ethyl-4,6-dimethoxy-pyrimidin-2-carboxylate (25 g, 1 eq.) in NH3/MeOH (7 M, 15 mL) was irradiated in a microwave reactor at 100° C. for 15 min. The solution was concentrated in vacuo to yield compound 286 as a beige solid in 100% yield. MS (ESI, EI+): m/z=184 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09284307B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-d5485e8e3cc54ecd98714dbc1ec745d5 |
| 出典メモ | uspto-grants-2016_03 |