Hydrochloric Acid → 5-(Dimethylamino)-N-(2-oxoethyl)naphthalene-1-sulfonamide
反応式
C[O:2][CH:3](OC)[CH2:4][NH:5][S:6]([C:9]1[C:18]2[C:13](=[C:14]([N:19]([CH3:21])[CH3:20])[CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]=1)(=[O:8])=[O:7].Cl>CO>[O:2]=[CH:3][CH2:4][NH:5][S:6]([C:9]1[C:18]2[C:13](=[C:14]([N:19]([CH3:21])[CH3:20])[CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]=1)(=[O:8])=[O:7]参加物
4
反応条件
- 温度
- 25 °C
実験手順
The acetal 11 (287 mg, 850 mop was dissolved in MeOH (1 mL) and coned HCl (0.5 mL) was added to the solution, which was stirred for 1 h at 25° C. The reaction mixture was then evaporated to dryness; the material left was dissolved in CH2Cl2 (10 mL) and the solution was washed with NaHCO3 (2 mL of a saturated aqueous solution). The organic layer was collected and was evaporated under low pressure to give the aldehyde as a light green foam, the total amount of which was used without further purification in the preparation of 12.