(1-Methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanol → (1-Methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanone

HRID 926501ノート

反応式

HRID 926501 の反応式
[CH3:1][N:2]1[C:6]([CH:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[OH:8])=[CH:5][N:4]=[CH:3]1>O1CCOCC1.[O-2].[O-2].[Mn+4]>[CH3:1][N:2]1[C:6]([C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)=[O:8])=[CH:5][N:4]=[CH:3]1

参加物

4

反応物 1

HCID 86715604(1-Methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanol

生成物 1

HCID 86715605(1-Methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanone

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 312751,4-Dioxane溶媒

実験手順

A heterogenous mixture of (1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanol (1.41 g, 7.45 mmol, Intermediate 33: step a) and manganese dioxide (3.24 g, 37.27 mmol) in 1,4-dioxane (52 mL) was stirred at 100° C. for 2 hours. The reaction mixture was then cooled to room temperature, filtered through Celite®, washed with DCM, and concentrated to provide the title compound as an off-white solid.

後処理

  1. filtrationfiltered through Celite®
  2. washwashed with DCM
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-b311ad1dec01437892ff3059d79c7e1d
出典データセット
uspto-grants-2016_03
特許番号
US09284308B2

反応ノート

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