2-(4-Bromo-phenyl)-N-{4-[2-(4-bromo-phenyl)-2-hydroxy-acetylamino]-phenyl}-2-hydroxy-acetamide → HCID 66654939、化合物

HRID 926658

反応式

HRID 926658 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](O)[C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19](=[O:29])[CH:20]([C:22]3[CH:27]=[CH:26][C:25]([Br:28])=[CH:24][CH:23]=3)O)=[CH:14][CH:13]=2)=[O:10])=[CH:4][CH:3]=1>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:17]3[C:12](=[CH:13][C:14]4[CH:20]([C:22]5[CH:27]=[CH:26][C:25]([Br:28])=[CH:24][CH:23]=5)[C:19](=[O:29])[NH:18][C:15]=4[CH:16]=3)[NH:11][C:9]2=[O:10])=[CH:4][CH:3]=1

参加物

3

反応物 1

HCID 680277402-(4-Bromo-phenyl)-N-{4-[2-(4-bromo-phenyl)-2-hydroxy-acetylamino]-phenyl}-2-hydroxy-acetamide

生成物 1

HCID 66654939HCID 66654939、化合物収率 83%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

2-(4-Bromo-phenyl)-N-{4-[2-(4-bromo-phenyl)-2-hydroxy-acetylamino]-phenyl}-2-hydroxy-acetamide (18.00 g, 33.70 mmol) (1.1) is added to concentrated sulfuric acid (180 cm3) at 21° C. in a 500 cm3 round-bottom flask. After 18 hours stirring, the reaction mixture is poured onto ice and filtered off. The recovered precipitate is washed with water and dried for 18 hours at 80° C. in a vacuum oven. The crude product is used without further purification (13.88 g, Yield: 83%).

後処理

  1. additionthe reaction mixture is poured onto ice
  2. filtrationfiltered off
  3. washThe recovered precipitate is washed with water
  4. customdried for 18 hours at 80° C. in a vacuum oven
  5. customThe crude product is used without further purification (13.88 g, Yield: 83%)

出典と根拠

ORDレコード
ord-613b378f1e3141bd94b9ef5f8a74633d
出典データセット
uspto-grants-2016_03
特許番号
US09287504B2

関連ノート

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