Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate → (R)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid

HRID 926748

反応式

HRID 926748 の反応式
Cl.[F:2][C:3]1[CH:4]=[CH:5][C:6]([O:14][CH3:15])=[C:7]([C@H:9]2[CH2:13][CH2:12][CH2:11][NH:10]2)[CH:8]=1.Br[C:17]1[CH:22]=[CH:21][N:20]2[N:23]=[CH:24][C:25]([C:26]([O:28]CC)=[O:27])=[C:19]2[CH:18]=1>>[F:2][C:3]1[CH:4]=[CH:5][C:6]([O:14][CH3:15])=[C:7]([C@H:9]2[CH2:13][CH2:12][CH2:11][N:10]2[C:17]2[CH:22]=[CH:21][N:20]3[N:23]=[CH:24][C:25]([C:26]([OH:28])=[O:27])=[C:19]3[CH:18]=2)[CH:8]=1

参加物

3

反応物 2

HCID 53249841Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylateHCID 66519187HCID 66519187、化合物

生成物 1

HCID 89634261(R)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid

実験手順

The title compound was prepared by a method substantially similar to that mentioned in step-5 and step-6 of example-3 using (R)-2-(5-Fluoro-2-methoxyphenyl)pyrrolidine hydrochloride (step-1 of example-269) and Ethyl 5-bromo-pyrazolo[1,5-a]pyridine-3-carboxylate to afford the product as white solid. MS (ESI): m/z 356.1 (M+H).

出典と根拠

ORDレコード
ord-3b758032f6684947952c3e6bf56fc7aa
出典データセット
uspto-grants-2016_03
特許番号
US09289419B2

関連ノート

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