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Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate → (R)-5-(2-(3,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate | HCID 53249841 | — |
| 反応物 | (r)-2-(3,5-Difluorophenyl)pyrrolidine hydrochloride | HCID 89618463 | — |
| 生成物 | (R)-5-(2-(3,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid | HCID 89618792 | — |
反応手順
The title compound was prepared by a method substantially similar to that mentioned in step-5 and step-6 of example-3 using (R)-2-(3,5-Difluorophenyl)pyrrolidine hydrochloride (step-1) and Ethyl 5-bromo-pyrazolo[1,5-a]pyridine-3-carboxylate to afford the product as white solid. MS (ESI): m/z 344.1 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09289419B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-baa9fe32e8ba4d28baab27a3f715f727 |
| 出典メモ | uspto-grants-2016_03 |