化工社化工社 化学情報印刷レポート · 研究参考用
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → N-methacryloylglycylglycyl-thiazolidine-2-thione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 反応物 | Methacryloylglycylglycine | HCID 10241886 | — |
| 反応物 | HCID 178527880 | HCID 178527880 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-methacryloylglycylglycyl-thiazolidine-2-thione | HCID 58455605 | — |
反応手順
The synthesis of MA-GG-TT was similar to the synthesis of MA-GFLG-TT in Example 1. N-methacryloylglycylglycine (MA-GG-OH) was coupled with 2-mercaptothiazoline in DCM mediated by EDCI in presence of catalytic amount of DMAP. After reaction, the product was purified by recrystallization from MeOH solution.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09289510B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-7570d324d8d74bb897fc76c6c33cdc28 |
| 出典メモ | uspto-grants-2016_03 |