化工社化工社 化学情報印刷レポート · 研究参考用
Sodium sulfate decahydrate → (4-Phenylsulfanylmethyl-phenyl)-methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium sulfate decahydrate | HCID 62649 | — |
| 反応物 | Methyl 4-(phenylsulfanylmethyl)benzoate | HCID 366566 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (4-Phenylsulfanylmethyl-phenyl)-methanol | HCID 59255239 | 95.4% |
反応手順
Methyl 4-(phenylsulfanylmethyl)benzoate (1.07 g) was dissolved in THF (14 mL), added with lithium aluminum hydride (200 mg) in small portions under ice cooling, and stirred for 40 minutes at the same temperature. Under ice cooling, sodium sulfate decahydrate was added in small portions and filtered through Celite. The solvent was evaporated under reduced pressure. The residues were suspended in hexane and collected by filtration to obtain the title compound (910 mg) as a white powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09290440B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-515455be59cd4491a9782fc76afb926c |
| 出典メモ | uspto-grants-2016_03 |