Carbon tetrabromide → HCID 17966545、化合物
反応式
O[CH2:2][C:3]1[CH:13]=[CH:12][C:6]2[S:7](=[O:11])(=[O:10])[CH2:8][CH2:9][C:5]=2[CH:4]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:34]>C(Cl)Cl>[Br:34][CH2:2][C:3]1[CH:13]=[CH:12][C:6]2[S:7](=[O:11])(=[O:10])[CH2:8][CH2:9][C:5]=2[CH:4]=1参加物
5
実験手順
To a solution of 5-hydroxymethyl-2,3-dihydro-benzo[b]thiophene 1,1-dioxide (185 mg, 0.93 mmol) in CH2Cl2 (6 mL) was added triphenylphosphine (294 mg, 1.12 mmol) and carbon tetrabromide (371 mg, 1.12 mmol). After stirring for 14 h at rt, all volatiles were removed under reduced pressure. 5-Bromomethyl-2,3-dihydro-benzo[b]thiophene 1,1-dioxide (218 mg, 90%) was isolated by chromatography (33-50% ethyl acetate in hexanes).
後処理
- customall volatiles were removed under reduced pressure
出典と根拠
- ORDレコード
- ord-32e20032029249eaa96720c3bbbfedb0
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09290465B2
反応ノート
読み込み中…