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HRID 927119作成日：2026年10月27日

4-Bromo-3-fluorobenzotrifluoride → 3,4-bis(Benzyloxy)-6-{2-[2-fluoro-4-(trifluoromethyl)phenyl]-ethynyl}pyridazine

https://huagongshe.com/reaction/927119

反応式

関与物質

役割名称HCID仕込み量
反応物4-Bromo-3-fluorobenzotrifluorideHCID 142414—
反応物3,4-Bis(benzyloxy)-6-((3-methyl-4-(trifluoromethyl)phenyl)-ethynyl)pyridazineHCID 71269897—
反応物3,4-Bis(benzyloxy)-6-ethynylpyridazineHCID 86677025—
生成物3,4-bis(Benzyloxy)-6-{2-[2-fluoro-4-(trifluoromethyl)phenyl]-ethynyl}pyridazineHCID 7127051116%

反応手順

Prepared as described for 3,4-bis(benzyloxy)-6-((3-methyl-4-(trifluoromethyl)phenyl)-ethynyl)pyridazine (Intermediate 74) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 1-bromo-2-fluoro-4-(trifluoromethyl)benzene in 16% yield.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09290456B2
出典データセットuspto-grants-2016_03
ORD IDord-47ade3eda15144e2a56378d05b86e767
出典メモuspto-grants-2016_03