Ethyl Acetate → HCID 178424566、化合物

HRID 927143

反応式

HRID 927143 の反応式
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C([O:24][C:25]1[N:26]=[N:27][C:28]([C:39]#[C:40][C:41]2[CH:46]=[CH:45][C:44]([F:47])=[C:43]([CH3:48])[CH:42]=2)=[CH:29][C:30]=1[O:31]CC1C=CC=CC=1)C1C=CC=CC=1.C(OCC)(=O)C>CO>[F:47][C:44]1[CH:45]=[CH:46][C:41]([CH2:40][CH2:39][C:28]2[CH:29]=[C:30]([OH:31])[C:25](=[O:24])[NH:26][N:27]=2)=[CH:42][C:43]=1[CH3:48]

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 712703693,4-Bis(benzyloxy)-6-[2-(4-fluoro-3-methylphenyl)ethynyl]pyridazine2 回HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

生成物 1

HCID 178424566HCID 178424566、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Prepared by the same method as for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-[2-(4-fluoro-3-methylphenyl)ethynyl]pyridazine (Intermediate 29) except that the solvent mixture used for the hydrogenation was made up of ethyl acetate and methanol (1:1) and the final material was recrystallised from ethyl acetate.

後処理

  1. customthe final material was recrystallised from ethyl acetate

出典と根拠

ORDレコード
ord-2b934151f75d4befb6839552acdcb1c9
出典データセット
uspto-grants-2016_03
特許番号
US09290456B2

関連ノート

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