(E)-3,4-bis(benzyloxy)-6-(4-(trifluoromethyl)styryl)pyridazine → HCID 178518816、化合物

反応式

OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C([O:24][C:25]1[N:26]=[N:27][C:28](/[CH:39]=[CH:40]/[C:41]2[CH:46]=[CH:45][C:44]([C:47]([F:50])([F:49])[F:48])=[CH:43][CH:42]=2)=[CH:29][C:30]=1[O:31]CC1C=CC=CC=1)C1C=CC=CC=1>>[OH:31][C:30]1[C:25](=[O:24])[NH:26][N:27]=[C:28]([CH2:39][CH2:40][C:41]2[CH:46]=[CH:45][C:44]([C:47]([F:49])([F:48])[F:50])=[CH:43][CH:42]=2)[CH:29]=1

参加物

反応物 2

HCID 86677029(E)-3,4-bis(benzyloxy)-6-(4-(trifluoromethyl)styryl)pyridazine2 回

HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

生成物 1

HCID 178518816HCID 178518816、化合物

実験手順

Prepared by the same method as for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from (E)-3,4-bis(benzyloxy)-6-(4-(trifluoromethyl)styryl)pyridazine (Intermediate 44) except that the product was recrystallised from a mixture of heptane and ethyl acetate.

後処理

customwas recrystallised from a mixture of heptane and ethyl acetate

出典と根拠

ORDレコード: ord-88b08a1f49c04cb7997e5d9ea73b55df
出典データセット: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09290456B2

反応ノート

読み込み中…

参加物